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25th August 2009, 01:00 AM
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Moisturisers linked to skin cancer
Whilst investigating the potential of caffeine as an agent for the inhibition of skin cancer, US researchers innocently selected four commercially available skin creams to act as potential caffeine vehicles: Dermabase, Dermovan, Eucerin and Vanicream. As a precaution, they chose to first assess the possible carcinogenic properties of one of the creams, Dermabase. To their suprise, the analysis revealed significant increases in both number and volume of tumours in mice. The research took a consequent U-turn with individual tests then carried out on each of the four creams. All showed significant tumourigenic effects after a 17 week trial period. The worst offender, Dermovan, demonstrated a 95% increase in the number of developed tumours compared with the control mice. Human relevance It is fair to say that the onset of skin cancer in mice follows a recognisable course to that of human skin cancers. However, reaching conclusions as to whether these findings can be applied to humans must be done with extreme caution. ‘Mice models have been used for years and have translated well to humans’ says principal investigator Allan Conney. ‘Epidemiology work is now needed to determine whether our findings also apply to the human population.’ Interestingly, a Custom Blend cream lacking both sodium lauryl sulphate and mineral oil, a known stimulator of UVB tumourigenesis, was also used in the study. The cream demonstrated no significant increases in either number or volume of tumours per mouse. Industry Interest A patent application has been filed for the Custom Blend cream on behalf of the university and Johnson and Johnson. Although the researchers were keen to point out that they recieved no funding from Johnson and Johnson, the patent application would suggest a real interest and concern from the leading manufacturers. The researchers were unable to comment further on either the chemical components responsible or the cellular mechanism involved. Nor were they explicit in saying where, if anywhere, the future directions lay. 
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25th September 2009, 11:40 AM
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Irradiation of mice with UVB twice a week for 20 weeks resulted in mice with a high risk of developing skin tumors over the next several months in the absence of further irradiation with UVB. Topical applications of commercially available moisturizing creams once a day, 5 days a week for 17 weeks to these high-risk mice increased significantly the rate of formation of tumors and the rate of increase in tumor size per mouse.
The results indicate that several commercially available moisturizing creams increase the rate of formation and number of tumors when applied topically to UVB-pretreated high-risk mice. Further studies are needed to determine the effects of topical applications of moisturizing creams on sunlight-induced skin cancer in humans.
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