Dear all,

Pesqui Odontol Bras. 2006 Sep;20(3):196-201.
Comparative therapeutic use of Risedronate and Calcarea phosphorica -
allopathy versus homeopathy - in bone repair in castrated rats.
Werkman C, Segnini Senra G, Rocha RF, Brandao AA.
Sao Paulo State University.

Osteoporosis, a disease characterized by progressive bone loss, has been
the target of several studies in the past few years. It results in a
much higher risk for fractures and might cause slower bone lesion
healing. The aim of this work was to study the effects of Risedronate
(allopathic medicine) and Calcarea phosphorica 6CH (homeopathic
medicine) on the repair of bone lesions in male rats with osteoporosis
induced by castration. Eighty-four three-month-old rats were used
divided into four groups of twenty-one animals each. Three groups where
castrated and one group was submitted to Sham surgery. One month later,
cortical lesions were made in all animals' tibiae and, after one day,
the different experimental treatments began according to the following
groups: CR - castrated/Risedronate (1 mg/kg/day); CCp -
castrated/Calcarea phosphorica 6CH (3 drops/day); CP - castrated/placebo
and SP - Sham/placebo. The animals were sacrificed at seven, fourteen
and twenty-eight days after the beginning of the treatments and had
their tibiae removed. Digital radiographs of the tibiae were taken and
analyzed in order to evaluate the optical density of the defect area.
Then, they were decalcified and processed for histological and
histomorphometrical analysis. The data were submitted to ANOVA, and to
the Tukey and Dunnett tests (5%). The allopathic and homeopathic
treatments led to different bone formation as regards remodeling and
maturation aspects. Further research is necessary to access the
resistance and quality of the newly formed bone.
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All the best,

Gaby

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Gaby Rottler,
Germany
rottler (AT) curantur (DOT) de

http://www.curantur.de
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