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There is very little difference between the Gonococcus mutating to Meningococcus when attacked by antibiotics, and this change in the AIDS virus. Every new academic year at University , when the students are as interested in sex as in study -´- Gonorrhoea .is regularly “ cured “ by antibiotics – and a consequence is that there are regular outbreaks of meningococcal Meningitis. Why , when it is accepted that ´Flu virus can mutate in a matter of weeks , is that knowledge not carried over into the study of other viral infections. The announcement of an unusually aggressive and highly drug-resistant strain of HIV has ignited a storm of criticism and disagreement from AIDS experts and activists. But at the recent 12th Conference on Retroviruses and Opportunistic Infections, David Ho—head of the Aaron Diamond AIDS Research Center in New York—defended his decision to alert public-health officials about a patient who had shown a rapid progression to full-blown AIDS, and whose viral strain was resistant to three of four classes of HIV drugs. “Given the lack of scientific clarity, we believed that, from a public-health perspective, the most prudent thing to do was to notify the New York Department of Health and Mental Hygiene”, Ho said in a special session devoted to this case. “And that is the decision we stand by today.” But because this was only a single patient, critics have questioned the wisdom of making a public announcement before all of the data have been assembled and analysed. Similar case studies have also been reported, including two Canadian patients with drug-resistant and rapidly progressing HIV strains. (AIDS 2003; 17: 1256–58) “The case in New York seems to be an extension of what we previously reported”, said Julio Montaner (University of British Columbia, Vancouver, BC, Canada), who treated both patients. “The patient in New York has more resistance and has progressed within a shorter period of time.” Montaner points out that a small percentage of patients infected with wild-type virus can have very rapid progression, while a small percentage can have very slow progression. “So it's not clear right now if the cases that we are starting to see truly represent the beginning of a new epidemic, or a supervirus as such.” Ho stated that it has been known for a number of years that the transmission of multidrug-resistant (MDR) virus is possible, as is rapid progression following acute infection. In this case, there appeared to be a convergence of the MDR virus and rapid progression in a person who has had many high-risk sexual contacts and who used methamphetamine. “We cannot conclude if this is due to an aggressive virus or a genetic predisposition”, said Ho. “We do not know if this is a single isolated event or if there are additional cases out there.” The viral sequence is now being compared with those in the data-base at the Los Alamos National Laboratory, with the hope of finding a closely related HIV-1 strain that might provide an epidemiological linkage to this case. Thus far, the patient does not appear to have any predisposing genetic markers, but testing is still underway. |
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| Thread | Thread Starter | Forum | Replies | Last Post |
| mutation and vaccines. | passkey | Homeopathy Discussion | 3 | 4th June 2005 01:12 PM |