Yrs. ago I owned a book[can't remember the title or author} that went into great depth explaining primary reactions and secondary reactions concerning intake of gross substances and potentized rem. of same substance.
When someone drinks a cup of coffee, the body initially recognizes the caffeine, for only a split second, as a sleep inducing substance{primary reaction} and immediately overreacts to this, and vital force steps in, reflexively, producing biochemical reactions that do the opposite and crude coffee acts on many as a stimulant.
This is why coff., in potency produces {as long as it is not used too often} is widely accepted as a sleep aid.
With opium, {simplistically}, reverse process occurs.
I only offer this to those whose curiosity constantly drives them to the uncovering of core truths and a richer understanding of why homeopathy can work such wonders!

"God has a few of us whom He whispers in the ear; The rest may reason and welcome: 'tis we musicians know" Browning
Best regards, Fredric.