hi gpm, I understand from reading another post that you are looking for guidence from the original prescriber. Sorry I couldn't be of more help, its hard to really get a sense of what you are describing when you can't see it and feel it for yourself. I would probably take notice of Chris' post in wondering if there is a relation with carc. Could this developement be signifying a change in course of treatment? If this woman is not returning your calls is there anyone else you might be able to speak to? Let me know if there is anything I can do to help out.