Back to basics. The only dose which will act curatively is the least dose, which can still affect a change. Now this is an individual situation. It can mean that any of the available potencies can be indicated and it can mean that from any of the suitable potencies any amount can be required. Now with potencies below a 12C or 30X this amount may vary but for all higher potencies a single pellet will be sufficient since you are administering the quality of Oscillococcinum, the matrix, but not any material quantity. Much more crucial I find the question whether this remedy is actually indicated. You can achieve great changes with homoeopathy and eradicate diseases and tendencies for diseases. You can do great mischieve with homoeopathics and spoil the rest of your life's health and the health of your offspring. Now Oscillococcinum would be indicated if it resembles your suffering closer then any other homoeopathic remedy, otherwise not and there are no exceptions to this rule. Homoeopathics are not designed to bring you quickly back into a functional state but they are designed to help your life force to conquer suffering per se. Now if your are prone to come down with a very similar complaint again and again and you administer the very same remedy again and again you actually increase this very weakness in yourself eventually to a stage where it is irreversible. Make sure that when you take homoeopathics that they resemble the totality of your suffering and that you apply the minimum dose, ie one pellet once only. Should the remedy not work by improving your overall health and happiness then you have failed with your choice. No problem, take your case again and administer another remedy. Make sure that you listen to the symptoms of your body and mind. Do not try to push body and mind into a state of functionality when the only thing lacking is a few days break from life's duties.