Years ago...he would take that once in awhile. 24 hours after he took it...his whole demeanor would change...he'd be happy where he was grumpy. He would change his clothes..bathe, etc. But he hasn't been grumpy...or moody...so I wouldn't think of giving him a remedy. But I did give him med 200c last year...maybe a dose of sulpher now might last longer...but I'd rather wait until his personality gets ugly.