Placebo effect is generally defined as a general feeling of feeling better, but always wears off after some time and cannot indefinitively be reinduced. (The body knows the trick after a few times.)On the other hand, in susceptibles, it may work neary always. Ity is not so much what the patient says or the exact cjoice of words, but more a question of bearing and countenance. The palcebo effect never produces these. If you see a harried face the first time and a realxed face the second time, you know something has happened. It is undeniable and canno be explained by placebo-effect. The intensity and the pathological and physiological changes are other indicators.